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The Grand Exchange takes 2% of most sales, capped at 5m coins per item. A specific list of items is exempt from it entirely, and on those items the whole spread between buy and sell is yours. Anything selling for under 50 coins is also effectively untaxed, because 2% of such a small number rounds down to nothing.
The exempt list exists mostly to protect low-level supplies and a few special cases from having a tax layered onto already-thin margins. That means most exempt items are cheap and high-turnover, so profit comes from repeated volume rather than a large margin per unit.
Because there is no tax to subtract, the margin column here is the same before and after tax — which is not true anywhere else on this site.